Colchicine Toxicity
نویسندگان
چکیده
منابع مشابه
Increased autophagy accelerates colchicine-induced muscle toxicity.
Colchicine treatment is associated with an autophagic vacuolar myopathy in human patients. The presumed mechanism of colchicine-induced myotoxicity is the destabilization of the microtubule system that leads to impaired autophagosome-lysosome fusion and the accumulation of autophagic vacuoles. Using the MTOR inhibitor rapamycin we augmented colchicine’s myotoxic effect by increasing the autopha...
متن کاملColchicine prevents tumor necrosis factor-induced toxicity in vivo.
Tumor necrosis factor (TNF) toxicity was induced in vivo by intravenous administration of 15 micrograms of recombinant murine TNF-alpha per kg to galactosamine-sensitized mice. Within 8 h, the animals developed a fulminant hepatitis. Intravenous administration of 0.5 mg of colchicine per kg at 19 and 4 h prior to TNF challenge protected the animals against hepatitis. Lipopolysaccharide (LPS)-st...
متن کاملAnti-colchicine Fab fragments prevent lethal colchicine toxicity in a porcine model: a pharmacokinetic and clinical study.
BACKGROUND Colchicine poisoning is commonly lethal. Colchicine-specific Fab fragments increase rat urinary colchicine clearance and have been associated with a good outcome in one patient. We aimed to develop a porcine model of colchicine toxicity to study the pharmacokinetics and efficacy of ovine Fab. METHODS A Göttingen minipig critical care model was established and serial blood samples t...
متن کاملAttenuation of Colchicine Toxicity in Drug-resistant Cancer Cells by Co-treatment with Anti-malarial Drugs.
BACKGROUND/AIM Colchicine (COL) is a well-known and potent microtubule targeting anticancer agent. The purpose of our study was to identify conditions that increase sensitization of COL-resistant cancer cells that overexpress P-glycoprotein (P-gp). MATERIALS AND METHODS The anti-malarial drugs chloroquine (CHL), mefloquine (MEF) and primaquine (PRI) have been shown to increase sensitization i...
متن کاملThe Protective Role of Colchicine on Diclofenac Sodium Induced Hepatorenal Toxicity in Albino Rats Model
Diclofenac (DIC) is a widely used as an antiinflammatory drug and it is used as the toxicant in hepatoprotective studies. In the present study, hepato-renal protective activity of Colchicine against DIC induced liver and kidney injury in albino rats was assessed. Animals were injected with Diclofenac sodium at the single dose of 150 mg/ kg body weight daily for 28 days. Oral administration of c...
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ژورنال
عنوان ژورنال: JACC: Case Reports
سال: 2020
ISSN: 2666-0849
DOI: 10.1016/j.jaccas.2020.02.014